blastermaster
Destroyer Mode features powered up mutants waiting to take on Jason and SOPHIA III. On top-down view maps, enemies can only be damaged by using certain guns. On side view maps, defeating enemies creates extra danger. While the challenge is greater than Normal Mode, if you saved the Earth once before, you should be able to do it again! Enjoy this tougher adventure!
— Destroyer Mode Game Start Description • Blaster Master Zero

Destroyer Mode is a special Jason-only mode in Blaster Master Zero that was released in Version 1.2. It is a more challenging play mode than the normal game, and is meant to give advanced players an additional challenge.

Destroyer Mode, initiated for new games within the Extra menu, must first be unlocked by completing Normal Mode, requiring the player to collect all key items from the first eight areas and defeat Invem Sophia. Save files for Destroyer Mode are marked with a red-on-black "DESTROYER" label near the upper-right corner of the details display.

Changes from Normal Mode

General

Items

Many of SOPHIA III's main weapons and sub-weapons (and one of Jason's sub-weapons) have been given different locations.

Area Boss Normal Mode Power-up Item Destroyer Mode Power-up Item
Area 1 Thousand Vios Thunder Breaker Life Up
Drap Trappers Ignition Bomb Life Up
Area 2 Biby Legion Homing Missile Ignition Bomb
Crabularva Laser Shot Shield Mine
Area 3 Obliteration Lasers Flash Bomb
Photophage Jump Booster
Area 4 Tadroll's Snack Time Maximum Shot
Spark Salamander Spark Tackle Laser Shot
Area 5 Ambush Room Shield Mine Homing Missile
Gurnahide Turret
Area 6 Peeper's Den Cannon Shot Spark Tackle
Remote Blaster Remote Blast
Area 7 S-1000 Generator Life Up Thunder Breaker
Venom Master Acceleration Blast
Area 8 Cell Rejection Life Up Cannon Shot